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Soft tissue and hard tissue engineering in oral and maxillofacial surgery.

Identifieur interne : 008174 ( Main/Exploration ); précédent : 008173; suivant : 008175

Soft tissue and hard tissue engineering in oral and maxillofacial surgery.

Auteurs : Rainer Schmelzeisen [Allemagne] ; Ronald Schimming ; Michael Sittinger

Source :

RBID : pubmed:14507132

Descripteurs français

English descriptors

Abstract

Autologous, allogenic and alloplastic materials for bony reconstruction in the cranio-maxillofacial area have specific drawbacks, thus stimulating the ongoing search for new (bio-) materials. Cultivated skin and mucosa grafts are in routine clinical use in head and neck reconstruction but so far, to the best of our knowledge, no successful clinical application has been described of periosteum-derived tissue-engineered bone for augmentation of the edentulous posterior maxilla. In a pilot clinical study, augmentation of the posterior maxilla was carried out using a bone matrix derived from mandibular periosteum cells on an Ethisorb fleece. In this paper we demonstrate the fabrication of the matrix, its clinical application, and histological results in two patients. Our results suggest that periosteum-derived osteoblasts on a suitable matrix can form lamellar bone within four months after transplantation and provide a reliable basis for implant insertion.

PubMed: 14507132


Affiliations:


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Le document en format XML

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<nlm:affiliation>Department of Oral and Cranio-Maxillofacial Surgery, Albert-Ludwigs-University, Freiburg i. Br., Germany. kloesel@zmk2.ukl.uni-freiburg.de</nlm:affiliation>
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<term>Alveolar Ridge Augmentation (methods)</term>
<term>Biocompatible Materials (chemistry)</term>
<term>Bone Matrix (physiology)</term>
<term>Bone Matrix (transplantation)</term>
<term>Bone Transplantation (methods)</term>
<term>Humans</term>
<term>Jaw, Edentulous, Partially (surgery)</term>
<term>Maxilla (surgery)</term>
<term>Oral Surgical Procedures</term>
<term>Orthopedic Procedures</term>
<term>Osteoblasts (physiology)</term>
<term>Osteogenesis (physiology)</term>
<term>Periosteum (cytology)</term>
<term>Pilot Projects</term>
<term>Polyesters (chemistry)</term>
<term>Polyglycolic Acid (chemistry)</term>
<term>Tissue Engineering (methods)</term>
<term>Tissue and Organ Harvesting</term>
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<term>Acide polyglycolique ()</term>
<term>Humains</term>
<term>Ingénierie tissulaire ()</term>
<term>Matériaux biocompatibles ()</term>
<term>Maxillaire ()</term>
<term>Mâchoire partiellement édentée ()</term>
<term>Ostéoblastes (physiologie)</term>
<term>Ostéogenèse (physiologie)</term>
<term>Polyesters ()</term>
<term>Procédures de chirurgie maxillofaciale et buccodentaire</term>
<term>Procédures orthopédiques</term>
<term>Projets pilotes</term>
<term>Prélèvement d'organes et de tissus</term>
<term>Périoste (cytologie)</term>
<term>Reconstruction de crête alvéolaire ()</term>
<term>Trame osseuse (physiologie)</term>
<term>Trame osseuse (transplantation)</term>
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<term>Periosteum</term>
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<term>Jaw, Edentulous, Partially</term>
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<term>Maxillaire</term>
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<term>Prélèvement d'organes et de tissus</term>
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<div type="abstract" xml:lang="en">Autologous, allogenic and alloplastic materials for bony reconstruction in the cranio-maxillofacial area have specific drawbacks, thus stimulating the ongoing search for new (bio-) materials. Cultivated skin and mucosa grafts are in routine clinical use in head and neck reconstruction but so far, to the best of our knowledge, no successful clinical application has been described of periosteum-derived tissue-engineered bone for augmentation of the edentulous posterior maxilla. In a pilot clinical study, augmentation of the posterior maxilla was carried out using a bone matrix derived from mandibular periosteum cells on an Ethisorb fleece. In this paper we demonstrate the fabrication of the matrix, its clinical application, and histological results in two patients. Our results suggest that periosteum-derived osteoblasts on a suitable matrix can form lamellar bone within four months after transplantation and provide a reliable basis for implant insertion.</div>
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